Browsing by Author "Papageorgis, P."
Now showing items 1-15 of 15
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D-alpha-tocopheryl polyethylene glycol succinate (TPGS) induces cell cycle arrest and apoptosis selectively in Survivin-overexpressing breast cancer cells
Neophytou, Christiana M.; Constantinou, Constantina; Papageorgis, P.; Constantinou, Andreas I. (2014)d-alpha-tocopheryl polyethylene glycol succinate (TPGS) is a vitamin E derivative that has been intensively applied as a vehicle for drug delivery systems to enhance drug solubility and increase the oral bioavailability ...
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Hyaluronan-Derived Swelling of Solid Tumors, the Contribution of Collagen and Cancer Cells, and Implications for Cancer Therapy
Voutouri, C.; Polydorou, C.; Papageorgis, P.; Gkretsi, V.; Stylianopoulos, T. (2016)Despite the important role that mechanical forces play in tumor growth and therapy, the contribution of swelling to tumor mechanopathology remains unexplored. Tumors rich in hyaluronan exhibit a highly negative fixed charge ...
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Multiscale modelling of solid tumour growth: the effect of collagen micromechanics
Wijeratne, P. A.; Vavourakis, V.; Hipwell, J. H.; Voutouri, C.; Papageorgis, P.; Stylianopoulos, T.; Evans, A.; Hawkes, D. J. (2016)Here we introduce a model of solid tumour growth coupled with a multiscale biomechanical description of the tumour microenvironment, which facilitates the explicit simulation of fibre–fibre and tumour–fibre interactions. ...
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Pirfenidone normalizes the tumor microenvironment to improve chemotherapy
Polydorou, C.; Mpekris, F.; Papageorgis, P.; Voutouri, C.; Stylianopoulos, T. (2017)Normalization of the tumor microenvironment by selectively targeting components of the tumor extracellular matrix has been recently proposed to have the potential to decompress tumor blood vessels, increase vessel perfusion ...
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Remodeling components of the tumor microenvironment to enhance cancer therapy
Gkretsi, V.; Stylianou, A.; Papageorgis, P.; Polydorou, C.; Stylianopoulos, T. (2015)Solid tumor pathophysiology is characterized by an abnormal microenvironment that guides tumor progression and poses barriers to the efficacy of cancer therapies. Most common among tumor types are abnormalities in the ...
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Remodeling of extracellular matrix due to solid stress accumulation during tumor growth
Pirentis, A. P.; Polydorou, C.; Papageorgis, P.; Voutouri, C.; Mpekris, F.; Stylianopoulos, T. (2015)Solid stresses emerge as the expanding tumor displaces and deforms the surrounding normal tissue, and also as a result of intratumoral component interplay. Among other things, solid stresses are known to induce extensive ...
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Reversal of ER-β silencing by chromatin modifying agents overrides acquired tamoxifen resistance
Pitta, Chara A.; Papageorgis, P.; Charalambous, Christina; Constantinou, Andreas I. (2013)The purpose of this work is to determine the molecular mechanisms underlying tamoxifen resistance. We show here that ER-β is epigenetically silenced in a cell line with acquired tamoxifen resistance (MCF-7/TAM-R) and this ...
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Role of constitutive behavior and tumor-host mechanical interactions in the state of stress and growth of solid tumors
Voutouri, C.; Mpekris, F.; Papageorgis, P.; Odysseos, A. D.; Stylianopoulos, T. (2014)Mechanical forces play a crucial role in tumor patho-physiology. Compression of cancer cells inhibits their proliferation rate, induces apoptosis and enhances their invasive and metastatic potential. Additionally, compression ...
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Role of TGFβ in regulation of the tumor microenvironment and drug delivery (review)
Papageorgis, P.; Stylianopoulos, T. (2015)Deregulation of cell signaling homeostasis is a predominant feature of cancer initiation and progression. Transforming growth factor β (TGFβ) is a pleiotropic cytokine, which regulates numerous biological processes of ...
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Solid Stress Facilitates Fibroblasts Activation to Promote Pancreatic Cancer Cell Migration
Kalli, M.; Papageorgis, P.; Gkretsi, V.; Stylianopoulos, T. (2018)Pancreatic fibroblasts are continuously gaining ground as an important component of tumor microenvironment that dynamically interact with cancer cells to promote tumor progression. In addition, these tumor-infiltrated ...
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Sonic-hedgehog pathway inhibition normalizes desmoplastic tumor microenvironment to improve chemo- and nanotherapy
Mpekris, F.; Papageorgis, P.; Polydorou, C.; Voutouri, C.; Kalli, M.; Pirentis, A. P.; Stylianopoulos, T. (2017)Targeting the rich extracellular matrix of desmoplastic tumors has been successfully shown to normalize collagen and hyaluronan levels and re-engineer intratumoral mechanical forces, improving tumor perfusion and chemotherapy. ...
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Stress alleviation strategy in cancer treatment: Insights from a mathematical model
Mpekris, F.; Voutouri, C.; Papageorgis, P.; Stylianopoulos, T. (2018)Tumors generate mechanical forces during growth and progression, which are able to compress blood and lymphatic vessels, reducing perfusion rates and creating hypoxia. Tumor vessels-while nourishing the tumor-are usually ...
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Targeting IL13Ralpha2 activates STAT6-TP63 pathway to suppress breast cancer lung metastasis
Papageorgis, P.; Ozturk, S.; Lambert, A. W.; Neophytou, Christiana M.; Tzatsos, Alexandros; Wong, C. K.; Thiagalingam, S.; Constantinou, Andreas I. (2015)Introduction: Basal-like breast cancer (BLBC) is an aggressive subtype often characterized by distant metastasis, poor patient prognosis, and limited treatment options. Therefore, the discovery of alternative targets to ...
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Tranilast-induced stress alleviation in solid tumors improves the efficacy of chemo- and nanotherapeutics in a size-independent manner
Papageorgis, P.; Polydorou, Christiana; Mpekris, Fotios; Voutouri, Chrysovalantis; Agathokleous, Eliana A.; Kapnissi‐Christodoulou, Constantina P.; Stylianopoulos, Triantafyllos (2017)Accumulation of mechanical stresses during cancer progression can induce blood and lymphatic vessel compression, creating hypo-perfusion, hypoxia and interstitial hypertension which decrease the efficacy of chemo- and ...
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Tranilast-induced stress alleviation in solid tumors improves the efficacy of chemo- and nanotherapeutics in a size-independent manner
Papageorgis, P.; Polydorou, C.; Mpekris, F.; Voutouri, C.; Agathokleous, E.; Kapnissi-Christodoulou, C. P.; Stylianopoulos, T. (2017)Accumulation of mechanical stresses during cancer progression can induce blood and lymphatic vessel compression, creating hypo-perfusion, hypoxia and interstitial hypertension which decrease the efficacy of chemo- and ...